Investigating the molecular guts of endoderm formation using zebrafish
نویسندگان
چکیده
Abstract The vertebrate endoderm makes major contributions to the respiratory and gastrointestinal tracts all associated organs. Zebrafish humans share a high degree of genetic homology strikingly similar endodermal organ systems. Combined with multitude experimental advantages, zebrafish are an attractive model organism study development disease. Recent functional genomics studies have shed considerable light on gene regulatory programs governing early development, while advances in biological technological approaches stand further revolutionize our ability investigate formation, function Here, we discuss present understanding specification compared other vertebrates, how current emerging methods will allow refined enhanced analysis integration human data modeling link between non-coding sequence variants
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ژورنال
عنوان ژورنال: Briefings in Functional Genomics
سال: 2021
ISSN: ['2041-2649', '2041-2657']
DOI: https://doi.org/10.1093/bfgp/elab013